SidaGhanaV1, Main, Exploration, bibRecord, 000B96

Frequency and genotype of GB virus C among Iranian patients infected with HIV

Identifieur interne : 000B96 ( Main/Exploration ); précédent : 000B95; suivant : 000B97

Frequency and genotype of GB virus C among Iranian patients infected with HIV

Auteurs : Soheila Hekmat [Iran] ; Minoo Mohraz [Iran] ; Rouhollah Vahabpour [Iran] ; Sara Jam [Iran] ; Golnaz Bahramali [Iran] ; Mohammad Banifazl [Iran] ; Arezoo Aghakhani [Iran] ; Ali Eslamifar [Iran] ; Fereidoun Mahboudi [Iran] ; Rozita Edalat [Iran] ; Amitis Ramezani [Iran]

Source :

Journal of Medical Virology [ 0146-6615 ] ; 2008-11.

RBID : ISTEX:59963BE3AC4EA477D19EBCE87C0B7A39F5CD4B0C

Descripteurs français

Wicri :
- geographic : Iran.

English descriptors

Abstract

GB virus C (GBV‐C) infection is frequent in patients infected with the human immunodeficiency virus (HIV) due to similar transmission routes of these viruses. The aim of this study was to determine the rate of infection and genotypic characteristics of GBV‐C in this population. The presence of GBV‐C RNA was determined in serum samples of 106 patients infected with HIV by reverse transcriptase‐nested polymerase chain reaction. GBV‐C genotypes were determined by direct sequencing. Hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti‐HBs), hepatitis C antibody (anti‐HCV), alanine aminotransferase (ALT) levels, HIV viral load and CD4+ count were also tested in all patients. The overall prevalence of GBV‐C infection was 11.3% in HIV patients. There was no significant difference between patients with and without GBV‐C infection regarding age, sex, route of transmission, viral load, ALT levels, HBV and HCV co‐infection and treatment with antiretroviral drugs. 66.7% of patients with GBV‐C had a CD4+ count ≥200 and 33.3% had a CD4+ count <200 cells/mm3. Phylogenetic analysis revealed that all GBV‐C isolates were genotype 2, and classified as subtype 2a. GBV‐C infection is relatively common in patients infected with HIV. The prevailing GBV‐C genotype 2a in this study group concurred with reports from other parts of the Middle East. J. Med. Virol. 80:1941–1946, 2008. © 2008 Wiley‐Liss, Inc.

Url:

https://api.istex.fr/document/59963BE3AC4EA477D19EBCE87C0B7A39F5CD4B0C/fulltext/pdf

DOI: 10.1002/jmv.21314

Affiliations:

Iran

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Le document en format XML

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<author><name sortKey="Mohraz, Minoo" sort="Mohraz, Minoo" uniqKey="Mohraz M" first="Minoo" last="Mohraz">Minoo Mohraz</name>
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<author><name sortKey="Vahabpour, Rouhollah" sort="Vahabpour, Rouhollah" uniqKey="Vahabpour R" first="Rouhollah" last="Vahabpour">Rouhollah Vahabpour</name>
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<author><name sortKey="Banifazl, Mohammad" sort="Banifazl, Mohammad" uniqKey="Banifazl M" first="Mohammad" last="Banifazl">Mohammad Banifazl</name>
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<series><title level="j" type="main">Journal of Medical Virology</title>
<title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title>
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<idno type="eISSN">1096-9071</idno>
<imprint><biblScope unit="vol">80</biblScope>
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<biblScope unit="page" from="1941">1941</biblScope>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiretroviral drugs</term>
<term>Blood donors</term>
<term>Clinical characteristics</term>
<term>Clinical research department</term>
<term>Coinfected patients</term>
<term>Coinfection</term>
<term>Disease progression</term>
<term>Genotype</term>
<term>Genotypic characteristics</term>
<term>Haji molla hoseini</term>
<term>Hemodialysis patients</term>
<term>Hepatitis</term>
<term>Heterosexual contact</term>
<term>High prevalence</term>
<term>Human virus</term>
<term>Infection</term>
<term>Inner primers</term>
<term>Intravenous drug</term>
<term>Iran</term>
<term>Iranian</term>
<term>Iranian patients</term>
<term>Iranian research center</term>
<term>Kimura matrix</term>
<term>Muerhoff</term>
<term>Novel group</term>
<term>Nucleotide sequences</term>
<term>Other parts</term>
<term>Overall prevalence</term>
<term>Pasteur</term>
<term>Pasteur institute</term>
<term>Phylogenetic</term>
<term>Phylogenetic analysis</term>
<term>Phylogenetic tree</term>
<term>Positive patients</term>
<term>Prevalence</term>
<term>Roche diagnostics gmbh</term>
<term>Saudi arabia</term>
<term>Statistical analysis</term>
<term>Study group</term>
<term>Surface antigen</term>
<term>Tehran</term>
<term>Viral</term>
<term>Viral load</term>
<term>Virol</term>
<term>Virus</term>
<term>Virus genotypes</term>
<term>Virus infection</term>
<term>Virus type</term>
<term>West africa</term>
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<term>Blood donors</term>
<term>Clinical characteristics</term>
<term>Clinical research department</term>
<term>Coinfected patients</term>
<term>Coinfection</term>
<term>Disease progression</term>
<term>Genotype</term>
<term>Genotypic characteristics</term>
<term>Haji molla hoseini</term>
<term>Hemodialysis patients</term>
<term>Hepatitis</term>
<term>Heterosexual contact</term>
<term>High prevalence</term>
<term>Human virus</term>
<term>Infection</term>
<term>Inner primers</term>
<term>Intravenous drug</term>
<term>Iran</term>
<term>Iranian</term>
<term>Iranian patients</term>
<term>Iranian research center</term>
<term>Kimura matrix</term>
<term>Muerhoff</term>
<term>Novel group</term>
<term>Nucleotide sequences</term>
<term>Other parts</term>
<term>Overall prevalence</term>
<term>Pasteur</term>
<term>Pasteur institute</term>
<term>Phylogenetic</term>
<term>Phylogenetic analysis</term>
<term>Phylogenetic tree</term>
<term>Positive patients</term>
<term>Prevalence</term>
<term>Roche diagnostics gmbh</term>
<term>Saudi arabia</term>
<term>Statistical analysis</term>
<term>Study group</term>
<term>Surface antigen</term>
<term>Tehran</term>
<term>Viral</term>
<term>Viral load</term>
<term>Virol</term>
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<front><div type="abstract" xml:lang="en">GB virus C (GBV‐C) infection is frequent in patients infected with the human immunodeficiency virus (HIV) due to similar transmission routes of these viruses. The aim of this study was to determine the rate of infection and genotypic characteristics of GBV‐C in this population. The presence of GBV‐C RNA was determined in serum samples of 106 patients infected with HIV by reverse transcriptase‐nested polymerase chain reaction. GBV‐C genotypes were determined by direct sequencing. Hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti‐HBs), hepatitis C antibody (anti‐HCV), alanine aminotransferase (ALT) levels, HIV viral load and CD4+ count were also tested in all patients. The overall prevalence of GBV‐C infection was 11.3% in HIV patients. There was no significant difference between patients with and without GBV‐C infection regarding age, sex, route of transmission, viral load, ALT levels, HBV and HCV co‐infection and treatment with antiretroviral drugs. 66.7% of patients with GBV‐C had a CD4+ count ≥200 and 33.3% had a CD4+ count <200 cells/mm3. Phylogenetic analysis revealed that all GBV‐C isolates were genotype 2, and classified as subtype 2a. GBV‐C infection is relatively common in patients infected with HIV. The prevailing GBV‐C genotype 2a in this study group concurred with reports from other parts of the Middle East. J. Med. Virol. 80:1941–1946, 2008. © 2008 Wiley‐Liss, Inc.</div>
</front>
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<tree><country name="Iran"><noRegion><name sortKey="Hekmat, Soheila" sort="Hekmat, Soheila" uniqKey="Hekmat S" first="Soheila" last="Hekmat">Soheila Hekmat</name>
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<name sortKey="Aghakhani, Arezoo" sort="Aghakhani, Arezoo" uniqKey="Aghakhani A" first="Arezoo" last="Aghakhani">Arezoo Aghakhani</name>
<name sortKey="Bahramali, Golnaz" sort="Bahramali, Golnaz" uniqKey="Bahramali G" first="Golnaz" last="Bahramali">Golnaz Bahramali</name>
<name sortKey="Banifazl, Mohammad" sort="Banifazl, Mohammad" uniqKey="Banifazl M" first="Mohammad" last="Banifazl">Mohammad Banifazl</name>
<name sortKey="Edalat, Rozita" sort="Edalat, Rozita" uniqKey="Edalat R" first="Rozita" last="Edalat">Rozita Edalat</name>
<name sortKey="Eslamifar, Ali" sort="Eslamifar, Ali" uniqKey="Eslamifar A" first="Ali" last="Eslamifar">Ali Eslamifar</name>
<name sortKey="Jam, Sara" sort="Jam, Sara" uniqKey="Jam S" first="Sara" last="Jam">Sara Jam</name>
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<name sortKey="Mohraz, Minoo" sort="Mohraz, Minoo" uniqKey="Mohraz M" first="Minoo" last="Mohraz">Minoo Mohraz</name>
<name sortKey="Ramezani, Amitis" sort="Ramezani, Amitis" uniqKey="Ramezani A" first="Amitis" last="Ramezani">Amitis Ramezani</name>
<name sortKey="Ramezani, Amitis" sort="Ramezani, Amitis" uniqKey="Ramezani A" first="Amitis" last="Ramezani">Amitis Ramezani</name>
<name sortKey="Vahabpour, Rouhollah" sort="Vahabpour, Rouhollah" uniqKey="Vahabpour R" first="Rouhollah" last="Vahabpour">Rouhollah Vahabpour</name>
</country>
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Frequency and genotype of GB virus C among Iranian patients infected with HIV

Frequency and genotype of GB virus C among Iranian patients infected with HIV

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri